The vasculature of xenotransplanted human melanomas and sarcomas. 3. Morphometric studies

Morphometric measurements of xenotransplanted tumors allowed the evaluation of vascular distribution and density. The correlation between these two parameters and the amount of necrosis could be determined. A wide range of vascular densities between different tumors was measured. This extreme heterogeneity of vascular distribution and density was seen in the center as well as in the periphery of single tumors. Large avascular regions were identified in several tumors that were not necrotic. The distribution of the necrosis showed no zonal correlation, either. No correlation was observed between the density of vessels and the amount of necrosis.