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Updated: May 11, 2026
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Published on: September 15, 2017
TNF-α signalling and inflammation: interactions between old acquaintances.
1Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, 612 42 Brno, Czech Republic.
Summary
Tumor necrosis factor-alpha (TNF-α) is a key regulator of inflammation, influencing processes like vasodilation, edema, and fever. This review highlights TNF-α
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Inflammation is a critical component of innate immunity.
- Cytokine networks tightly regulate inflammatory processes.
- Tumor necrosis factor-alpha (TNF-α) is a pivotal pro-inflammatory cytokine within these networks.
Purpose of the Study:
- To review the multifaceted role of TNF-α in inflammation.
- To elucidate TNF-α's intracellular signaling pathways.
- To explore the connection between TNF-α and cancer development.
Main Methods:
- Comprehensive literature search of PubMed and Web of Science databases.
- Inclusion of studies providing evidence on TNF-α's involvement in inflammation, apoptosis, and cancer.
- Synthesis of existing research on TNF-α's biological functions.
Main Results:
- TNF-α significantly contributes to typical inflammatory features.
- Key roles include mediating vasodilation, edema, and leukocyte adhesion.
- TNF-α influences blood coagulation, oxidative stress, and fever induction.
Conclusions:
- TNF-α is a central mediator of inflammatory responses.
- Its signaling pathways are crucial for understanding inflammatory conditions.
- Emerging evidence links TNF-α to oncogenesis, warranting further investigation.
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