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Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

A general approach to DNA-programmable atom equivalents.

Chuan Zhang1, Robert J Macfarlane, Kaylie L Young

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Nature Materials
|May 21, 2013
PubMed
Summary

Researchers developed a universal method to create DNA-functionalized nanoparticles for building complex 3D colloidal crystals. This breakthrough enables precise control over crystal structure using diverse nanoparticle materials.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Nanoparticles and nucleic acids enable programmed formation of 3D colloidal crystals with controllable properties.
  • Current methods for DNA-functionalizing diverse nanoparticles are limited, restricting material variety.

Purpose of the Study:

  • To develop a general method for preparing DNA-functionalized nanoparticles irrespective of their chemical composition.
  • To expand the range of materials available for DNA-based colloidal crystallization.

Main Methods:

  • Coating aliphatic ligand-protected nanoparticles with an azide-bearing amphiphilic polymer.
  • Attaching DNA to the polymer shell via strain-promoted azide-alkyne cycloaddition (copper-free click chemistry).

Main Results:

  • Successful creation of nanoparticles with a high-density nucleic acid shell.
  • Demonstrated applicability across various nanoparticle compositions.
  • Established a versatile platform for DNA-guided nanoparticle assembly.

Conclusions:

  • The developed method overcomes limitations in preparing DNA-functionalized nanoparticles.
  • It opens up a vast range of materials for creating programmable colloidal crystals.
  • This advances the field of DNA-based self-assembly and materials design.