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Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...

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Related Experiment Video

Updated: May 11, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Social environmental effects on gene regulation.

Jenny Tung1, Yoav Gilad

  • 1Department of Evolutionary Anthropology, Duke University, Box 90383, Durham, NC, 27708, USA, jt5@duke.edu.

Cellular and Molecular Life Sciences : CMLS
|May 21, 2013
PubMed
Summary

Social adversity impacts health by altering gene regulation. Epigenetic mechanisms mediate these changes, offering insights into stress-related diseases and potential health interventions.

Area of Science:

  • Social neuroscience
  • Genomics
  • Epigenetics

Background:

  • Social environmental conditions, especially adversity, are linked to health and mortality in social mammals.
  • Previous research focused on neurological, endocrinological, and immunological effects of social adversity.
  • Emerging research investigates gene regulation's role in mediating social environmental impacts on health.

Purpose of the Study:

  • To explore the role of gene regulation in how social environments affect health.
  • To understand the mechanisms, including epigenetics, underlying these gene expression changes.
  • To identify genes involved in social environmental responses that may also influence disease susceptibility.

Main Methods:

  • Analysis of gene expression patterns in response to social conditions across species (rodents, primates, humans).

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Conditions Affecting Social Space in Drosophila melanogaster
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Conditions Affecting Social Space in Drosophila melanogaster

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Last Updated: May 11, 2026

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  • Investigation of regulatory mechanisms, with a focus on epigenetic modifications.
  • Correlation studies linking genes regulated by social environment to stressor susceptibility and disease.

    • Main Results:

    • Significant correlations found between social conditions and the regulation of numerous genes.
    • Epigenetic marks identified as key mediators of gene expression responses to the social environment.
    • Overlap observed between genes responding to social adversity and those linked to other stressors and diseases.

    Conclusions:

    • Gene regulation, particularly through epigenetics, is a crucial pathway connecting social adversity to health outcomes.
    • Understanding these gene regulatory mechanisms offers potential for developing novel strategies to mitigate the health effects of social adversity.
    • This research highlights a promising avenue for addressing health disparities linked to social environmental factors.