Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular adrenergic responses in morphine-dependent rats.

H Gustafsson1, M Delle, H Nilsson

  • 1Department of Physiology, University of Göteborg, Sweden.

Acta Physiologica Scandinavica
|June 1, 1990
PubMed
Summary

Morphine abstinence causes vasoconstriction, but this study found no evidence of increased peripheral artery response to nerve stimulation or noradrenaline in dependent rats. Smooth muscle sensitivity to adrenergic stimulation was actually reduced, refuting a peripheral vascular origin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiographers' role in the age of AI: A qualitative comparative multi case study.

Radiography (London, England : 1995)·2026
Same author

Influence of stress resilience in adolescence on long-term risk of psoriasis and psoriatic arthritis among men: A prospective register-based cohort study in Sweden.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Observations of a Solar Energetic Particle Event From Inside and Outside the Coma of Comet 67P.

Journal of geophysical research. Space physics·2023
Same author

BepiColombo mission confirms stagnation region of Venus and reveals its large extent.

Nature communications·2022
Same author

Inner southern magnetosphere observation of Mercury via SERENA ion sensors in BepiColombo mission.

Nature communications·2022
Same author

Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy.

Cardiovascular and interventional radiology·2022

Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuroscience

Background:

  • Morphine abstinence is linked to circulatory changes, including vasoconstriction and increased mean arterial pressure.
  • Decreased renal sympathetic nerve activity has been observed during morphine withdrawal.
  • The precise mechanisms driving vasoconstriction during morphine abstinence remain unclear, particularly regarding peripheral vascular involvement.

Purpose of the Study:

  • To investigate the potential contribution of peripheral vasculature to vasoconstriction during morphine abstinence.
  • To examine the contractile responses of peripheral arteries to nerve stimulation and noradrenaline in morphine-dependent rats.
  • To determine if chronic morphine treatment alters vascular smooth muscle sensitivity to adrenergic agents.

Main Methods:

Related Experiment Videos

  • Peripheral arteries were isolated from morphine-dependent and untreated rats.
  • Contractile responses were measured in vitro following transmural nerve stimulation.
  • Vascular responses to applied noradrenaline were assessed under paired conditions.

Main Results:

  • Chronic morphine treatment did not increase the contractile response of peripheral arteries to nerve stimulation.
  • Noradrenaline-induced vasoconstriction was not enhanced in arteries from morphine-dependent rats.
  • A reduction in smooth muscle sensitivity to adrenergic stimulation was observed in morphine-dependent rats.

Conclusions:

  • The study does not support a peripheral adrenergic mechanism as the cause of vasoconstriction during naloxone-precipitated morphine abstinence.
  • The observed vasoconstriction during morphine withdrawal is unlikely to originate from an enhanced peripheral vascular response.
  • Further research is needed to elucidate the central or other peripheral mechanisms involved in morphine abstinence-induced circulatory effects.