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Updated: May 11, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
The antiviral activities of tetherin
1Department of Infectious Disease, King's College London School of Medicine, London, UK. stuart.neil@kcl.ac.uk
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Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent advances in our understanding of tetherin's associated role in viral pattern recognition and the evidence for its role in limiting viral pathogenesis in vivo.
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