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Related Experiment Video

Updated: May 11, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Moderate-intensity single exercise session does not induce renal damage.

Koji Hiraki¹, Atsuko Kamijo-Ikemori, Takashi Yasuda

¹Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, Kanagawa, Japan.

Journal of Clinical Laboratory Analysis

|May 21, 2013

Summary

This summary is machine-generated.

A single moderate-intensity exercise session did not cause kidney damage in chronic kidney disease (CKD) patients. Researchers found no significant changes in urinary markers of renal injury after exercise.

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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

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Last Updated: May 11, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Area of Science:

Nephrology
Exercise Physiology
Biomarker Research

Background:

Chronic kidney disease (CKD) affects millions worldwide.
Understanding the impact of exercise on kidney health in CKD patients is crucial.
Urinary biomarkers like L-type fatty acid-binding protein (L-FABP) can indicate kidney dysfunction.

Purpose of the Study:

To investigate if a single moderate-intensity exercise session induces renal injury in CKD patients.
To assess changes in specific urinary biomarkers associated with kidney damage post-exercise.

Main Methods:

Adult CKD outpatients (n=31) not on renal replacement therapy participated.
Urine samples were collected pre- and post-exercise (20-min moderate-intensity).
Urinary L-FABP, albumin, N-acetyl-β-d-glucosaminidase (NAG), and α1-microglobrin (α1MG) were measured.

Main Results:

No significant increase in urinary L-FABP, albumin, NAG, or α1MG was observed post-exercise.
Specific subgroup analysis (eGFR < 30 ml/min/1.73 m²) showed similar non-significant findings.
Exercise did not elevate key markers of renal injury in CKD patients.

Conclusions:

A single bout of moderate-intensity exercise does not appear to cause acute renal injury in CKD patients.
Current findings suggest exercise is safe concerning acute kidney damage markers in this population.
Further research could explore long-term effects and different exercise intensities.