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Updated: May 11, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Peptide profiling of the route from Mahoney to Sabin, and return
Darja Kanduc1, Candida Fasano, Simona Lucia Bavaro
1Department of Biosciences, Biotechnologies and Pharmacological Sciences, University of Bari, Bari, Italy.
Abstract:
In order to define poliovirus (PV) neurovirulence at the molecular level, we comparatively analyze the primary amino acid sequence of Mahoney, a neurovirulent PV strain, versus (i) Sabin, an attenuated PV strain, and (ii) IS1, a PV isolate obtained in temporal association to a paralysis event from a polio vaccinated subject. We identify and describe 12 pentapeptides that, originally present in the Mahoney sequence, are changed in the non-neurovirulent Sabin strain, and, successively, restored in IS1 strain.
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