Related Experiment Video
Updated: May 11, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
23Na NMR relaxation studies of the Na-DNA/drug interaction
F Cesare Marincola1, M Casu, G Saba
1Dipartimento di Scienze Chimiche, Università degli Studi di Cagliari, Monserrato, Cagliari, Italy.
Abstract:
This Minireview covers the methodological approaches of (23)Na NMR spectroscopy to the study of the structure and dynamics of the DNA molecule, in particular the application of the (23)Na NMR quadrupolar relaxation to investigate the perturbations on the polyion surface due to exogenous agents. A brief description of the (23)Na NMR quadrupolar relaxation and of the models used to describe the distribution of counterions around DNA, and the results of the application of the (23)Na NMR relaxation to the study of the cation-DNA interaction are also shown. Following sections present results of the investigation on ligand-DNA interaction and on ordered DNA systems.
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