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Updated: May 11, 2026

Visualization of Recombinant DNA and Protein Complexes Using Atomic Force Microscopy
Published on: July 18, 2011
High-quality mapping of DNA-protein complexes by dynamic scanning force microscopy
1Physikalisches Institut, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Abstract:
Biomolecular complexes, nanocircles and aggregates of DNA and streptavidin (STV) are studied by dynamic scanning force microscopy. More structural details are observed with an improved dynamic mode assisted with a special feedback circuit (Q-control), as shown in the picture. Under otherwise identical conditions, these improvements indicate that the well cited models relating enlarged lateral size to the finite geometry of the SFM tip have to be modified for soft samples susceptible to tip-sample interactions.
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