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The Effect of Solifenacin on Cognitive Function following Stroke
1Department of Physical Medicine and Rehabilitation, Dongguk University Ilsan Hospital, Goyang-si, Republic of Korea.
Dementia and Geriatric Cognitive Disorders Extra
|May 21, 2013
Summary
Solifenacin, an anticholinergic, did not significantly impact short-term cognitive function in stroke patients. This study provides valuable data for clinicians prescribing anticholinergics to this population.
Area of Science:
- Neurology
- Pharmacology
Background:
- Stroke survivors often experience cognitive deficits.
- Anticholinergic medications are sometimes prescribed to stroke patients.
- The cognitive effects of anticholinergics in stroke are not well-established.
Purpose of the Study:
- To investigate the effect of solifenacin on cognitive function in post-stroke patients.
- To determine if solifenacin influences cognitive decline or improvement in stroke survivors.
Main Methods:
- Retrospective review of 66 stroke patients prescribed solifenacin for over 2 months.
- Matched control group based on sex and age.
- Comparison of changes in Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SB) scores.
Main Results:
- No significant difference in MMSE score changes between the solifenacin group (1.9 ± 5.2) and the control group (2.9 ± 3.7).
- No significant difference in CDR-SB score changes between the groups.
- Baseline MMSE scores were comparable between groups.
Conclusions:
- Solifenacin treatment did not adversely affect short-term cognitive performance in stroke patients.
- Findings suggest solifenacin may be safely used regarding cognitive function in this population.
- This information is relevant for prescribing anticholinergics to stroke patients.
