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Clinical Value of an Ambulatory-Based Antibiogram for Uropathogens in Children

Kevin W Dahle1, Ernest K Korgenski2, Adam L Hersh3

  • 1University of Utah School of Medicine.

Journal of the Pediatric Infectious Diseases Society
|May 21, 2013
PubMed

Insights

Pediatric urinary tract infections (UTIs) may benefit from specialized outpatient antibiotic guidelines. Developing an ambulatory pediatric antibiogram for Utah children showed Escherichia coli was common and treatable with narrower-spectrum antibiotics.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial stewardship

Background:

  • Broad-spectrum antibiotic use in pediatric urinary tract infections (UTIs) is common.
  • Lack of population-specific antibiograms contributes to suboptimal prescribing for ambulatory pediatric UTIs.

Purpose of the Study:

  • To compare a hospital-based antibiogram with a proposed ambulatory pediatric antibiogram for Utah children.
  • To evaluate the utility of an ambulatory-specific antibiogram for guiding antibiotic selection in pediatric UTIs.

Main Methods:

  • Retrospective analysis of pediatric UTI data from Utah.
  • Comparison of pathogen prevalence and antibiotic susceptibility patterns between hospital and ambulatory settings.
  • Evaluation of Escherichia coli as a key uropathogen.

Main Results:

  • Escherichia coli was a predominant pathogen in pediatric UTIs.
  • This pathogen demonstrated higher susceptibility to narrower-spectrum antibiotics in the ambulatory setting.
  • Significant differences were observed compared to a general hospital antibiogram.

Conclusions:

  • Ambulatory pediatric antibiograms are needed to optimize antibiotic prescribing for UTIs.
  • Tailored guidelines can support the use of narrower-spectrum agents, improving antimicrobial stewardship.
  • This study highlights the potential impact of localized, population-specific antibiograms.

Keywords:
AntibiogramBacterialDrug ResistanceEscherichia coliUrinary Tract Infections

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