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Updated: May 11, 2026
09:58
Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
[Relationship between advanced schistosomiasis and HBV infection]
1Fourth People's Hospital of Xiantao City, Hubei Province, Xiantao 433000, China.
Summary
Advanced schistosomiasis patients with Hepatitis B Virus (HBV) infection showed significantly higher rates of liver damage, cancer, and mortality. Co-infection with HBV exacerbates liver damage in advanced schistosomiasis.
Area of Science:
- Hepatology
- Infectious Diseases
- Parasitology
Context:
- Schistosomiasis is a parasitic disease with significant global health implications.
- Hepatitis B Virus (HBV) infection is a major cause of chronic liver disease worldwide.
- The interplay between schistosomiasis and HBV co-infection, particularly in advanced stages, requires further elucidation.
Purpose:
- To investigate the relationship between advanced schistosomiasis and HBV infection.
- To analyze the impact of HBV co-infection on liver function, liver cancer, and mortality in patients with advanced schistosomiasis.
Summary:
- A study of 250 advanced schistosomiasis patients revealed a 58.4% HBsAg positive rate.
- Patients with both advanced schistosomiasis and HBV infection exhibited significantly higher rates of abnormal liver function, jaundice, liver cancer, and mortality compared to those without HBV.
- Statistical analysis showed significant correlations (P < 0.05 or 0.01) between HBV infection and adverse liver-related outcomes.
Impact:
- HBV co-infection significantly worsens liver damage in individuals with advanced schistosomiasis.
- Findings highlight the critical need for integrated management strategies for co-infected patients.
- This research underscores the importance of screening for HBV in schistosomiasis patients to mitigate severe liver complications.
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