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Updated: May 11, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
Adipose tissue plasticity from WAT to BAT and in between
Yun-Hee Lee1, Emilio P Mottillo1, James G Granneman1
1Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Adipose tissue exhibits remarkable cellular and metabolic plasticity, offering new therapeutic targets for obesity-related diseases. Understanding its developmental origins and heterogeneity is key to unlocking these treatment avenues.
Area of Science:
- Metabolic science
- Cell biology
- Endocrinology
Background:
- Adipose tissue regulates energy balance via metabolic, cellular, and endocrine functions.
- Historically classified as white (anabolic) and brown (catabolic) adipose tissue.
- Recent findings reveal significant cellular heterogeneity and metabolic plasticity within adipose tissue.
Purpose of the Study:
- To review the developmental origins and cellular complexity of adipose tissue.
- To discuss progenitor cells contributing to adipogenesis.
- To explore pathological remodeling and identify therapeutic targets for obesity-related diseases.
Main Methods:
- Literature review of developmental biology and cell biology studies.
- Analysis of recent data on adipose tissue heterogeneity and plasticity.
- Synthesis of information on adipose tissue remodeling and therapeutic potential.
Main Results:
- Adipose tissue comprises diverse cell types with adaptable metabolic functions.
- Progenitor cells and their contribution to adipogenesis are crucial.
- Pathological remodeling of adipose tissue presents novel therapeutic targets.
Conclusions:
- Targeting the plasticity of adipose tissue offers promising strategies for treating obesity-related conditions.
- Further understanding of adipose tissue development and cellular dynamics is essential for therapeutic advancements.
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