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Updated: May 11, 2026

The Soft Agar Colony Formation Assay
Published on: October 27, 2014
Wnt signalling in pituitary development and tumorigenesis
T J G Chambers1, A Giles, G Brabant
1Endocrinology and Diabetes Group, Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Abstract:
Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.
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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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