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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Updated: May 11, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Published on: May 21, 2018

Inflammasomes in inflammatory bowel disease pathogenesis.

Ling-Yang Hao1, Xikui Liu, Luigi Franchi

  • 1Lycera Corporation, Ann Arbor, Michigan 48109, USA.

Current Opinion in Gastroenterology
|May 22, 2013
PubMed
Summary

Inflammasomes are key to intestinal health, regulating immune responses to microbes. Understanding their role in the gut microbiota may lead to new treatments for inflammatory bowel disease and gastrointestinal cancer.

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Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages

Published on: April 6, 2022

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Inflammasomes are protein complexes that activate inflammatory responses.
  • They are crucial for processing cytokines IL-1β and IL-18.
  • Nod-like receptor proteins assemble inflammasomes, impacting intestinal homeostasis.

Purpose of the Study:

  • To review the role of inflammasomes in intestinal homeostasis.
  • To summarize how inflammasomes control host defense, microbiota, and inflammation.
  • To highlight the centrality of Nod-like receptor proteins in these processes.

Main Methods:

  • Literature review focusing on inflammasome function in the intestine.
  • Analysis of recent findings on inflammasome-microbiota interactions.
  • Discussion of models for inflammasome roles in experimental colitis.

Main Results:

  • Inflammasomes critically regulate the gut immune system's interaction with commensal and pathogenic microbes.
  • They sense bacteria, influence microbial ecology, and prevent pathobiont emergence.
  • A model is proposed to reconcile conflicting data on inflammasomes in colitis.

Conclusions:

  • Understanding inflammasome signaling and gut microbiota interplay offers insights into innate immunity.
  • This knowledge may reveal novel therapeutic strategies for inflammatory bowel disease and gastrointestinal cancer.