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Mycophenolate as maintenance therapy for lupus nephritis with impaired renal function
F Rivera1, M L Illescas, E López-Rubio
1Sección de Nefrología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. friverahdez@senefro.org
American Journal of Nephrology
|May 22, 2013
Summary
Mycophenolate (MF) is effective for lupus nephritis (LN) maintenance therapy, even in patients with impaired renal function. This study confirms MF
Area of Science:
- Nephrology
- Rheumatology
- Pharmacology
Background:
- Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus.
- Mycophenolate (MF) is a common maintenance therapy for LN post-induction.
- The efficacy and safety of MF in LN patients with renal impairment are not well-established.
Purpose of the Study:
- To evaluate the efficacy and safety of MF as a maintenance therapy for LN.
- To assess the association between MF's effectiveness and patients' baseline renal function.
Main Methods:
- Retrospective analysis of 56 Spanish LN patients on MF maintenance therapy.
- Patients categorized into two groups based on estimated glomerular filtration rate (eGFR) at MF initiation: ≥60 ml/min/1.73 m(2) (Group 1) and <60 ml/min/1.73 m(2) (Group 2).
- Primary endpoints: renal relapse and response rates; Secondary endpoint: side effects.
Main Results:
- No significant differences in renal relapse rates at 6 or 12 months between groups.
- Similar response rates observed in both groups.
- Adverse events were infrequent and unremarkable across both groups.
Conclusions:
- Mycophenolate (MF) demonstrates comparable efficacy and safety as maintenance therapy for lupus nephritis (LN).
- MF is suitable for LN patients irrespective of their baseline renal function, including those with renal impairment.
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