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Updated: Feb 13, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Anaplastic lymphoma kinase (ALK1) immunohistochemistry in diagnostic dermatopathology; an update
John A Papalas1, Evan Kulbacki, Endi Wang
1Pathology Section, Eastern Dermatology and Pathology, Greenville, NC, USA. papalas@easternderm.com
Abstract:
The use of anaplastic lymphoma kinase antibodies (ALK1) as a diagnostic aid has expanded since becoming a routinely available immunohistochemical stain. Because the skin may be the site of a wide variety of hematolymphoid and fibroblastic proliferations, dermatopathologists commonly use ALK1 as part of a broader staining panel in diagnosing soft tissue and cutaneous hematolymphoid neoplasms. Furthermore, new entities and differential diagnostic contexts are emerging, which broaden the utility of ALK1 immunohistochemistry. We review the expanding role of ALK1 immunohistochemistry in contemporary dermatopathology.
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