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Related Experiment Video

Updated: May 11, 2026

Isolation and Identification of Limbal Niche Cells

Isolation and Identification of Limbal Niche Cells

Published on: October 27, 2023

Limbal epithelial cell therapy: past, present, and future.

Tor Paaske Utheim¹

¹Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.

Methods in Molecular Biology (Clifton, N.J.)

|May 22, 2013

Summary

Limbal stem cell deficiency (LSCD) can cause blindness by damaging the cornea. Current and emerging regenerative medicine strategies offer new hope for treating this condition.

Area of Science:

Ophthalmology
Regenerative Medicine
Stem Cell Biology

Background:

The cornea's transparency is vital for vision.
Corneal surface renewal depends on limbal stem cells.
Damage to these stem cells causes limbal stem cell deficiency (LSCD), potentially leading to blindness.

Purpose of the Study:

To discuss current and evolving therapeutic strategies for LSCD.
To highlight advances in regenerative medicine for treating LSCD.

Main Methods:

Review of established therapies for LSCD.
Exploration of alternative cell types and clinical approaches.
Discussion of regenerative medicine advancements.

Main Results:

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Published on: October 24, 2018

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

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Last Updated: May 11, 2026

Isolation and Identification of Limbal Niche Cells

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Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells

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Published on: October 24, 2018

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

Established LSCD therapy using ex vivo expanded limbal epithelial cells is under refinement.
Novel therapeutic approaches, including alternative cell types and clinical strategies, are emerging.
Significant progress is being made in regenerative medicine for LSCD.

Conclusions:

LSCD is a significant cause of blindness requiring effective treatments.
Regenerative medicine offers promising avenues for LSCD therapy.
Ongoing research and clinical advancements are crucial for improving outcomes in LSCD patients.