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Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive

Jesse Dawson1, Panniyammakal Jeemon, Lucy Hetherington

  • 1Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, Western Infirmary, University of Glasgow, Glasgow, United Kingdom.

Hypertension (Dallas, Tex. : 1979)
|May 22, 2013
PubMed

Insights

High serum uric acid levels did not affect blood pressure control in hypertensive patients but were linked to declining kidney function and increased mortality risk, particularly in women.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Serum uric acid's role in hypertension and renal dysfunction is under investigation.
  • Understanding this relationship is crucial for managing cardiovascular and renal health in hypertensive patients.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and longitudinal changes in blood pressure, renal function, and cardiovascular outcomes.
  • To analyze the impact of serum uric acid on mortality in a large cohort of treated hypertensive patients.

Main Methods:

  • Utilized data from the Glasgow Blood Pressure Clinic database, including baseline serum uric acid and longitudinal blood pressure and renal function measures.
  • Employed generalized estimating equations to analyze relationships between uric acid quartiles, blood pressure, and estimated glomerular filtration rate (eGFR).
  • Applied Cox proportional hazard models to assess mortality risks associated with serum uric acid levels.

Main Results:

  • Serum uric acid levels did not correlate with longitudinal changes in systolic or diastolic blood pressure.
  • Higher serum uric acid levels were associated with a greater decline in eGFR, especially in women.
  • All-cause and cardiovascular mortality were significantly higher across increasing quartiles of serum uric acid in women, but not in men.

Conclusions:

  • Serum uric acid is not associated with blood pressure control in treated hypertensive adults.
  • Elevated serum uric acid is a significant predictor of renal function decline and increased mortality risk in women with hypertension.

Keywords:
hypertensionmortalityrenal functionuric acidxanthine oxidase

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