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Updated: May 11, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Health of children classified as underweight by CDC reference but normal by WHO standard
Alan Meyers1, Katherine Joyce, Sharon M Coleman
1Department of Pediatrics, Boston Medical Center, Boston, MA 02118, USA. afmeyers@bu.edu
Insights
Children classified as underweight by CDC 2000 but normal by WHO 2006 standards still face higher risks of adverse health outcomes. This highlights the importance of considering growth chart differences in pediatric health assessments.
Area of Science:
- Pediatric Health
- Growth Monitoring
- Nutritional Assessment
Background:
- Pediatric growth references are crucial for identifying nutritional status.
- Discrepancies exist between different growth standards, impacting classification.
- The Centers for Disease Control and Prevention (CDC) 2000 and World Health Organization (WHO) 2006 standards differ in defining underweight.
Purpose of the Study:
- To evaluate health status in children classified as underweight by CDC 2000 but normal by WHO 2006 standards.
- To compare health outcomes across different underweight classification groups.
- To understand the clinical implications of using different growth references.
Main Methods:
- Cross-sectional study involving 18,420 children aged 6-24 months across 7 US cities.
- Children categorized based on CDC 2000 and WHO 2006 underweight criteria.
- Health outcomes assessed via caregiver ratings, developmental status, and hospitalization history.
- Multiple logistic regression used to analyze associations between categories and outcomes.
Main Results:
- Children underweight by CDC 2000 but not WHO 2006 showed significantly higher odds of adverse health outcomes.
- Children underweight by both criteria exhibited the highest odds of poor health.
- Adjusted odds ratios for fair/poor health rating were 2.54 (CDC only) and 3.76 (both criteria) compared to not underweight.
Conclusions:
- Reclassification from underweight (CDC 2000) to normal weight (WHO 2006) does not eliminate associated health risks.
- Children may experience morbidities linked to underweight even when meeting newer growth standards.
- Clinical vigilance is necessary when interpreting growth data across different standards.
Objective:
To ascertain measures of health status among 6- to 24-month-old children classified as below normal weight-for-age (underweight) by the Centers for Disease Control and Prevention (CDC) 2000 growth reference but as normal weight-for-age by the World Health Organization (WHO) 2006 standard.
Methods:
Data were gathered from children and primary caregivers at emergency departments and primary care clinics in 7 US cities. Outcome measures included caregiver rating of child health, parental evaluation of developmental status, history of hospitalizations, and admission to hospital at the time of visit. Children were classified as (1) not underweight by either CDC 2000 or WHO 2006 criteria, (2) underweight by CDC 2000 but not by WHO 2006 criteria, or (3) underweight by both criteria. Associations between these categories and health outcome measures were assessed by using multiple logistic regression analysis.
Results:
Data were available for 18 420 children. For each health outcome measure, children classified as underweight by CDC 2000 but normal by WHO 2006 had higher adjusted odds ratios (aORs) of adverse health outcomes than children not classified as underweight by either; children classified as underweight by both had the highest aORs of adverse outcomes. For example, compared with children not underweight by either criteria, the aORs for fair/poor health rating were 2.54 (95% confidence interval: 2.20-2.93) among children underweight by CDC but not WHO and 3.76 (3.13-4.51) among children underweight by both.
Conclusions:
Children who are reclassified from underweight to normal weight in changing from CDC 2000 to WHO 2006 growth charts may still be affected by morbidities associated with underweight.
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