Corrected thrombolysis in myocardial infarction frame count and ejection fraction in patients undergoing primary
Hossein Vakili1, Roxana Sadeghi, Mahdiyeh Tabkhi
1Associate Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Lower corrected thrombolysis in myocardial infarction frame count (CTFC) in the infarct-related artery is linked to better ejection fraction (EF) three months after primary percutaneous coronary intervention for ST-elevation myocardial infarction.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Imaging
Background:
- ST-segment elevation myocardial infarction (STEMI) requires timely reperfusion.
- Primary percutaneous coronary intervention (PPCI) is a standard treatment for STEMI.
- Assessing microvascular function post-PPCI is crucial for predicting outcomes.
Purpose of the Study:
- To evaluate the association between corrected thrombolysis in myocardial infarction frame count (CTFC) of the infarct-related artery (IRA) and ejection fraction (EF).
- To determine the predictive value of CTFC on left ventricular function three to six months after PPCI in STEMI patients.
Main Methods:
- 78 STEMI patients undergoing PPCI were analyzed.
- Corrected thrombolysis in myocardial infarction frame count (CTFC) was measured using a digital system.
- Left ventricular ejection fraction (EF) was assessed by Simpson's method at discharge and 3-6 months post-PPCI.
Main Results:
- No significant association was found between EF at discharge and CTFC.
- A significant positive association between lower CTFC (≤20) and higher EF was observed at three months post-PPCI (P=0.007).
- Patients with CTFC > 20 showed a trend towards lower EF at three months.
Conclusions:
- Lower CTFC of the IRA after PPCI for STEMI is associated with improved left ventricular ejection fraction at three months.
- CTFC may serve as a valuable marker for microvascular reperfusion and predicting recovery of cardiac function post-STEMI.
Background:
This study aimed to assess the associations between corrected thrombolysis in myocardial infarction frame count (CTFC) of the infarct-related artery (IRA) and ejection fraction (EF) after three-six months in patients who underwent primary percutaneous coronary intervention (PPCI) for ST segment elevation myocardial infarction (STEMI).
Methods:
CTFC was determined by a digital system for 78 patients. EF was measured through Simpson's method upon discharge and three-six months later. The subjects were divided into two groups of CTFC ≤ 20 (n = 54) and CTFC > 20 (n = 24). Association between CTFC and EF were then specified.
Results:
CTFC ≤ 20 and CTFC > 20 were present in 69.2% and 30.8% of the patients, respectively. There was no significant difference between the two groups regarding baseline characteristics. EF at the time of discharge was 42.1% ± 10.2% and 43.5% ± 11.4% in groups with CTFC ≤ 20 and > 20, respectively. There was no significant association between EF at discharge and CTFC (P = 0.611). After three months, EF changed to 49.6% ± 8.7% and 41.6 ± 12.4% in the groups with CTFC ≤ 20 and CTFC > 20, respectively. Three months after PPCI, EF and CTFC had a significant relation (P = 0.007). Cumulative number and percentage of shock and death were 3 (3.8%) and 2 (2.6%), respectively.
Conclusion:
Lower CTFC of the infarct-related artery in patients undergoing PPCI for STEMI was associated with higher left ventricular ejection fraction after three months.
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