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TLR-4 and VEGF polymorphisms in chronic periaortitis.

Fabiola Atzeni1, Luigi Boiardi, Augusto Vaglio

  • 1Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy.

Plos One
|May 22, 2013
PubMed
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Vascular Endothelial Growth Factor (VEGF) gene variations may influence Chronic Periaortitis (CP) risk, particularly the non-aneurysmal idiopathic retroperitoneal fibrosis (IRF) form. Specific VEGF alleles are linked to complications like ureteral obstruction and deep vein thrombosis in CP patients.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Chronic periaortitis (CP) is a rare fibro-inflammatory condition affecting the abdominal aorta, with distinct idiopathic retroperitoneal fibrosis (IRF) and inflammatory abdominal aortic aneurysm (IAAA) forms.
  • Understanding genetic factors influencing CP susceptibility and clinical presentation is crucial for disease management.

Purpose of the Study:

  • To investigate the association between Toll-like receptor 4 (TLR-4) and Vascular Endothelial Growth Factor (VEGF) gene polymorphisms and the risk and clinical features of Chronic Periaortitis (CP).

Main Methods:

  • Genotyping of 102 CP patients and 200 controls for TLR-4 (+896 A/G) and VEGF (+936 C/T, -634 C/G, -2549 I/D) polymorphisms.
  • Patients were categorized by CP type (IRF vs. IAAA) and presence of atherosclerotic disease.

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Main Results:

  • No significant differences in studied polymorphisms between CP patients and controls.
  • VEGF +936 T allele carriage was higher in IRF patients compared to IAAA patients (26.5% vs. 5.3%).
  • VEGF I allele carriers showed increased risk of ureteral obstruction (83.8%) and conservative treatment (48.5%). II homozygosity correlated with deep vein thrombosis (30.4%).

Conclusions:

  • VEGF +936 C/T polymorphism may increase the risk of developing the non-aneurysmal IRF form of CP.
  • Specific VEGF polymorphisms (I allele, II homozygosity) are associated with increased risks of ureteral obstruction and deep vein thrombosis in CP patients.