Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical and molecular landscape of thalamic glioma.

Neuro-oncology·2026
Same author

Human Hematopoietic Stem Cells Enhance Maturational Differentiation of hiPSC-Derived Cardiomyocytes on Xeno-Free MatriClone-Plastic via EGFR/MAPK/ERK Signaling Pathway.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Mahonia-derived carbon dots for dual-ion ratiometric sensing and cellular bioimaging.

Analytical methods : advancing methods and applications·2026
Same author

Selective blockade of γc pathway ameliorates alopecia areata in a humanized murine model.

The Journal of investigative dermatology·2026
Same author

Base editing of Artemis mutations ex vivo sheds light on gene therapy for Artemis-deficient SCID.

Advanced biotechnology·2026
Same author

Luteolin enhances antitumor immunity of B7-H3-targeted bispecific natural killer cell engagers against non-small cell lung cancer.

International journal of biological sciences·2026

Related Experiment Video

Updated: May 11, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

AliquotG: an improved heuristic algorithm for genome aliquoting.

Zelin Chen1, Shengfeng Huang, Yuxin Li

  • 1State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, College of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.

Plos One
|May 22, 2013
PubMed
Summary

This study introduces a new algorithm to reconstruct ancient polyploid genomes from extant ones, minimizing genome rearrangement distance. The method accurately recovers ancestral gene order and shows higher accuracy than previous approaches.

More Related Videos

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

Automated Gel Size Selection to Improve the Quality of Next-generation Sequencing Libraries Prepared from Environmental Water Samples
13:26

Automated Gel Size Selection to Improve the Quality of Next-generation Sequencing Libraries Prepared from Environmental Water Samples

Published on: April 17, 2015

Related Experiment Videos

Last Updated: May 11, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

Automated Gel Size Selection to Improve the Quality of Next-generation Sequencing Libraries Prepared from Environmental Water Samples
13:26

Automated Gel Size Selection to Improve the Quality of Next-generation Sequencing Libraries Prepared from Environmental Water Samples

Published on: April 17, 2015

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Extant genomes can descend from ancient polyploid genomes.
  • Reconstructing ancestral genomes is crucial for understanding genome evolution.
  • The genome aliquoting problem aims to minimize genome rearrangement distance.

Purpose of the Study:

  • To develop improved algorithms for the genome aliquoting problem using double cut and join (DCJ) distance.
  • To accurately reconstruct ancient polyploid genomes from extant descendants.
  • To analyze genome evolution in vertebrates after whole-genome duplication events.

Main Methods:

  • Developed a new algorithm utilizing partial and contracted partial graphs.
  • The algorithm locally minimizes the double cut and join (DCJ) distance.
  • Applied the algorithm to reconstruct ancestral vertebrate genomes after two rounds of whole-genome duplication (2R-WGD).

Main Results:

  • The new algorithm reliably recovers ancestral gene order, even for ancient polyploid genomes.
  • Demonstrated higher accuracy compared to an earlier method using simulation data.
  • Calculated DCJ distance for modern vertebrate genomes and their 2R-WGD ancestor, indicating a slowed rearrangement rate.

Conclusions:

  • The developed algorithm offers improved accuracy for reconstructing ancient polyploid genomes.
  • The findings suggest a significant slowdown in genome rearrangement rates post-2R-WGD in vertebrates.
  • The open-source software AliquotG is available for researchers.