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Related Experiment Video

Updated: May 11, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

Oral cellular neurothekeoma.

Nader Emami¹, Faisal Zawawi, Rania Ywakim

¹Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada H3A 1A1.

Case Reports in Otolaryngology

|May 22, 2013

Summary

A rare intraoral cellular neurothekeoma, a skin tumor, was diagnosed in a teenage girl. Complete surgical removal resulted in no recurrence after 16 months, suggesting a favorable prognosis for this oral lesion.

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Area of Science:

Oral Pathology
Dermatology
Oncology

Background:

Cellular neurothekeoma is a rare cutaneous tumor with unclear origins.
Intraoral involvement of this tumor is exceptionally uncommon in medical literature.
This report details a unique case of oral cellular neurothekeoma.

Purpose of the Study:

To report a rare case of intraoral cellular neurothekeoma.
To describe the histopathologic features and immunohistochemical profile of the tumor.
To document the clinical outcome following surgical management.

Main Methods:

A case report of a 15-year-old female with an intraoral lesion.
Histopathologic examination of the tumor.
Immunohistochemical analysis using CD63, vimentin, and NKI-C3 markers.
Surgical excision and clinical follow-up.

Main Results:

The intraoral lesion exhibited characteristics of cellular neurothekeoma.
Histopathology revealed spindle to epithelioid cells in micronodules with a whorled pattern.
Tumor cells tested positive for CD63, vimentin, and NKI-C3.
The patient underwent complete excision with no signs of recurrence at 16 months.

Conclusions:

Intraoral cellular neurothekeoma, though rare, can occur in adolescents.
Histopathology and immunohistochemistry are crucial for diagnosis.
Complete surgical excision appears to be an effective treatment, leading to a good prognosis.