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Crystalline and amorphous gold in chrysiasis.

H P Benn¹, B von Gaudecker, M Czank

¹II. Medizinische Klinik und Poliklinik, Universität Kiel, Federal Republic of Germany.

Archives of Dermatological Research

|January 1, 1990

Summary

This study investigated gold deposits in the skin of rheumatoid arthritis patients. Different gold forms were found in sun-exposed versus non-exposed skin, but not linked to rashes.

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Area of Science:

Dermatology
Materials Science
Rheumatology

Background:

Parenteral gold therapy is used for rheumatoid arthritis.
Gold deposits accumulate in skin tissues over time.
The physical state and location of gold in the skin are not fully understood.

Purpose of the Study:

To characterize the dermal heavy metal content in patients treated with gold.
To investigate the differences in gold aggregation patterns and physicochemical states in sun-exposed versus non-UV-exposed skin.
To correlate gold deposition with the occurrence of skin rash.

Main Methods:

Transmission electron microscopy (TEM) of skin biopsy specimens.
X-ray microanalysis and electron diffraction for heavy metal content determination.
Light microscopy for histological examination.

Main Results:

Dermal gold aggregations varied in pattern and physicochemical state between sun-exposed and non-UV-exposed skin.
Amorphous gold formations were observed in the upper dermis of non-UV-exposed skin.
Crystalline spherical gold particles were found predominantly in melanophages beneath solar-irradiated epidermis.
No correlation was found between skin rash and the physicochemical state of dermal gold.

Conclusions:

Gold deposition in the skin is heterogeneous and influenced by UV exposure.
UV radiation may induce changes in the physicochemical state of gold deposits.
The observed gold deposition patterns do not appear to be the cause of gold-induced skin rashes.

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