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Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility

Huan Zhang1, Yu-Liang Su, Herbert Yu

  • 1Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

Cancer Biology & Medicine
|May 22, 2013
PubMed
Abstract

Insights

The miR-196a-2 gene polymorphism rs11614913 is linked to increased cancer susceptibility. This risk is particularly elevated for lung, breast, and colorectal cancers in Asian populations.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • MicroRNAs regulate gene expression and are implicated in cancer development.
  • The miR-196a-2 polymorphism, specifically rs11614913, has been investigated for its role in cancer susceptibility.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between the miR-196a-2 rs11614913 polymorphism and overall cancer risk.

Main Methods:

  • A meta-analysis of 27 independent case-control studies.
  • Involved 10,435 cancer cases and 12,075 controls.
  • Analyzed the rs11614913 polymorphism in miR-196a-2.

Main Results:

  • A significant association between rs11614913 and cancer risk was observed across four genetic models.
  • The C allele correlated with higher risks for lung, breast, and colorectal cancers.
  • Increased cancer risk was noted among Asian populations but not Caucasians.

Conclusions:

  • The miR-196a-2 polymorphism rs11614913 is associated with cancer susceptibility.
  • This association is particularly significant for lung, colorectal, and breast cancers in Asian individuals.
Keywords:
MIRN196 microRNAhumanmeta-analysisneoplasmspolymorphism

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