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Updated: May 11, 2026
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
MRI manifestions correlate with survival of glioblastoma multiforme patients
Wen-Bin Li1, Kai Tang, Qian Chen
1Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Objective:
To identify the correlation between magnetic resonance manifestation and survival of patients with glioblastoma multiforme (GBM).
Methods:
The magnetic resonance imaging (MRI) images of 30 glioblastoma patients were collected. Imaging features including degrees of contrasted area, edema surrounding the tumor, and intensity in T2-weighted imaging were selected to determine their correlation with patient survival. The relationship between imaging and survival time was studied using SPSS 19.0 software. Kaplan-Meier survival analysis and log-rank test were used to compare the survival curves.
Results:
Patients with ≤5% contrasted enhancement area of tumor had longer overall survival (OS) than those with >5% contrasted enhancement area of tumor. Patients without edema surrounding the tumor had longer OS than those with edema. Patients with tumor of hyperintensity and/or isointensity in T2-weighted imaging had longer OS than those with hyperintensity and/or isointensity and hypointensity.
Conclusions:
Some MR imaging features including degrees of contrasted area, edema surrounding the tumor, and intensity in T2-weighted imaging are correlated with the survival of patients with GBM. These features can serve as prognostic indicators for GBM patients.
Insights
Magnetic resonance imaging (MRI) features like tumor enhancement, edema, and T2-weighted intensity correlate with glioblastoma multiforme (GBM) patient survival. These findings can help predict prognosis for GBM patients.
Area of Science:
- Neuro-oncology
- Radiology
- Medical Imaging
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with a poor prognosis.
- Accurate prognostic indicators are crucial for guiding treatment strategies and patient management.
Purpose of the Study:
- To investigate the correlation between specific magnetic resonance imaging (MRI) features and the overall survival (OS) of patients diagnosed with GBM.
Main Methods:
- Retrospective analysis of MRI scans from 30 GBM patients.
- Evaluation of imaging features: contrasted enhancement area, peritumoral edema, and T2-weighted signal intensity.
- Statistical analysis using SPSS 19.0, including Kaplan-Meier survival analysis and log-rank tests.
Main Results:
- Limited contrasted enhancement (≤5%) was associated with longer OS.
- Absence of peritumoral edema correlated with improved OS.
- Tumors with hyperintensity and/or isointensity on T2-weighted imaging showed longer OS compared to those with hypointensity.
Conclusions:
- Certain MRI features, including contrasted enhancement extent, edema presence, and T2-weighted signal intensity, are significant prognostic indicators for GBM patients.
- These imaging biomarkers can aid in predicting survival outcomes and informing clinical decision-making for GBM.
