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Related Experiment Video

Updated: May 11, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Improvement in hemodynamic response using a quadripolar LV lead.

Fernando Cabrera Bueno¹, Javier Alzueta Rodríguez, José Olagüe de Ros

¹Hospital Universitario Virgen de Victoria, Málaga, Spain. fonendo@hotmail.com

Pacing and Clinical Electrophysiology : PACE

|May 23, 2013

Summary

Quadripolar leads offer more left ventricle pacing options than traditional bipolar leads, potentially enhancing cardiac output (CO). Studies show quadripolar leads can improve CO compared to conventional pacing methods.

Keywords:

cardiac output cardiac resynchronization quadripolar lead

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Last Updated: May 11, 2026

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Published on: January 31, 2019

Area of Science:

Cardiology
Biomedical Engineering
Medical Devices

Background:

Quadripolar leads provide 10 pacing configurations, exceeding traditional bipolar leads.
These configurations may influence hemodynamic parameters and cardiac output (CO).

Purpose of the Study:

To evaluate if quadripolar lead pacing vectors can enhance cardiac output (CO).
To compare CO across various quadripolar pacing configurations and traditional methods.

Main Methods:

Cardiac output (CO) was measured using ECHO in 51 patients within 7 days of device implantation.
Pacing was assessed in "no-pacing" and all 10 quadripolar configurations, distinguishing traditional (tip-ring, tip-RVC, ring-RVC) and nontraditional vectors.
The optimal configuration maximized CO while maintaining a capture threshold <3 V and adequate safety margin.

Main Results:

The mean best CO with traditional quadripolar vectors (4.16 L/min) and all configurations (4.33 L/min) surpassed baseline non-paced CO (3.64 L/min).
The best quadripolar lead configuration yielded higher CO than the best traditional configuration.
Nontraditional vectors unique to quadripolar leads achieved the highest CO in 53% of patients.

Conclusions:

Quadripolar leads offer enhanced pacing capabilities for acute CO augmentation.
These leads provide superior options for optimizing cardiac function compared to conventional bipolar leads.