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Related Experiment Video

Updated: May 11, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Endemic pemphigus foliaceus in the Peruvian Amazon.

A G Ortega-Loayza¹, W Ramos, E L Gutierrez

¹Department of Dermatology, Virginia Commonwealth University, Richmond, VA, USA. aortegaloayza2@mcvh-vcu.edu

Clinical and Experimental Dermatology

|May 23, 2013

Summary

Endemic pemphigus foliaceus (EPF) in Peru involves IgG autoantibodies targeting desmoglein 1 (Dsg1). Peruvian EPF patients exhibit humoral responses consistent with South American cases.

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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Published on: June 17, 2025

Area of Science:

Immunodermatology
Autoimmunity
Epidemiology

Background:

Endemic pemphigus foliaceus (EPF) is an epidermal blistering disease.
Characterized by IgG autoantibodies against desmoglein 1 (Dsg1).
Reported in Brazil, Colombia, Tunisia, and Peru.

Purpose of the Study:

Characterize humoral response to Dsg1 and Dsg3 autoantibodies in Peruvian EPF patients.
Investigate specific IgG subclasses against Dsg1.
Assess anti-Dsg3 autoantibody presence.

Main Methods:

Indirect immunofluorescence (IIF) on human skin and monkey esophagus.
Immunoprecipitation with recombinant Dsg1 and Dsg3.
ELISA for IgG and its subclasses against Dsg1 and Dsg3.

Main Results:

IIF detected intercellular autoantibodies in over 80% of patients.
All sera immunoprecipitated Dsg1; 6.25% immunoprecipitated Dsg3.
ELISA showed anti-Dsg1 in 81.25%, anti-Dsg3 in 31.25%. IgG1, IgG2, and IgG4 were prominent against Dsg1.

Conclusions:

Peruvian EPF shares immunological features with other South American EPF cases.
Strong anti-Dsg1 response is characteristic.
Presence of anti-Dsg3 antibodies noted.