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Celiac disease in children with urolithiasis

Engin Menekşe1, Mukadder Ayşe Selimoğlu, Ismail Temel

  • 1Department of Pediatrics, İnönü University Faculty of Medicine, Malatya, Turkey. ayseselimoglu@hotmail.com

The Turkish Journal of Pediatrics
|May 23, 2013
PubMed

Insights

This study found higher celiac disease (CD) seropositivity in children with urolithiasis compared to controls. However, biopsy-proven CD rates did not differ significantly between groups, suggesting further investigation is needed.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Immunology

Background:

  • Celiac disease (CD) is linked to kidney disease, but its prevalence in pediatric urolithiasis remains unstudied.
  • Urolithiasis in children may share underlying immunological or genetic factors with CD.

Purpose of the Study:

  • To determine the prevalence of celiac disease in infants and children diagnosed with urolithiasis.
  • To compare CD seropositivity and biopsy-proven rates between children with and without urolithiasis.

Main Methods:

  • A case-control study included 187 infants and children with urolithiasis and 278 matched healthy controls.
  • Screening for CD involved tissue transglutaminase (tTG) immunoglobulin A (IgA) testing.
  • Seropositive individuals underwent upper gastrointestinal endoscopy with duodenal biopsy for confirmation.

Main Results:

  • Seropositivity for tTG IgA was higher in the urolithiasis group (3.7%) compared to controls (0.3%) (p=0.008).
  • Biopsy-proven CD was diagnosed in 1% of children with urolithiasis and 0% of controls.
  • No significant difference in biopsy-proven CD was observed between the groups, irrespective of age.

Conclusions:

  • While serological screening suggests a potential association, biopsy-proven celiac disease prevalence is similar in children with and without urolithiasis.
  • This study highlights the importance of considering CD in children with kidney stones, although definitive links require further research.

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