Related Experiment Video

Updated: May 11, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

The relationship between urinary tract infection and calcium excretion in children

Ayça Altıncık1, Ferah Sönmez, Nevin Semerci

  • 1Department of Pediatrics, Adnan Menderes University, Aydin, Turkey. ferahsonmez@yahoo.com

The Turkish Journal of Pediatrics
|May 23, 2013
PubMed

Insights

Children with urinary tract infections (UTI) show higher urinary calcium excretion before treatment compared to healthy children. This elevated calcium level normalized after treatment, suggesting a link between UTI and calcium metabolism in pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Infectious Diseases

Background:

  • Urinary tract infections (UTI) are common in children.
  • Altered urinary calcium excretion is a potential factor in pediatric urological conditions.
  • Understanding the relationship between UTI and urinary calcium is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the association between urinary tract infection (UTI) and urinary calcium excretion in children.
  • To assess changes in urinary calcium levels before, during, and after UTI treatment.
  • To explore the influence of infection characteristics on urinary calcium excretion.

Main Methods:

  • A case-control study involving 82 children with UTI and 82 matched controls.
  • Measurement of 24-hour urinary calcium excretion and urine calcium/creatinine ratio (UCa/cr).
  • Evaluation of UCa/cr percentiles and correlation with infection site, symptoms, family history, and imaging.

Main Results:

  • Pre-treatment UCa/cr ratios were significantly higher in children with UTI compared to the control group (p=0.04).
  • Urinary calcium excretion normalized after UTI treatment.
  • No significant correlation was found between pre-treatment UCa/cr and sex, infection location, family history, or radiological findings.

Conclusions:

  • Children with UTI exhibit elevated urinary calcium excretion prior to treatment.
  • Urinary calcium levels tend to normalize following successful UTI treatment.
  • Further research may elucidate the clinical significance of these findings in pediatric UTI management.

More Related Videos

Establishment and Characterization of UTI and CAUTI in a Mouse Model08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Related Concept Videos

Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...