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Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[Calciphylaxis, renal failure and gout. A patient with hyperuricemia as a risk factor for death]
Marco Ulises Martínez-Martínez1, Susana Román-Acosta, Juan Manuel Alvarez-Reyes
1Departamento de Medicina Interna, Hospital General de Zona 1, Instituto Mexicano del Seguro Social, San Luis Potosí, San Luis Potosí, México. marcomtzmtz@hotmail.com.
Insights
Hyperuricemia, a component of metabolic syndrome, significantly increases mortality risk when combined with calciphylaxis. Early identification and management are crucial for high-risk patients.
Area of Science:
- Nephrology
- Cardiology
- Rheumatology
Background:
- Gout and calciphylaxis are inflammatory conditions independently linked to high mortality.
- Metabolic syndrome, characterized by obesity, hypertension, and hypertriglyceridemia, often coexists with gout.
- The co-occurrence of hyperuricemia and calciphylaxis presents an 80% mortality risk.
Background:
gout is an inflammatory arthritis that frequently is associated with obesity, alcohol consumption, hypertension and hypertriglyceridemia. The calciphylaxis is characterized by metastatic calcification to small and medium vessels. Both are associated independently with high mortality. When hyperuricemia and the calciphylaxis are present, the death risk is 80 %.
Clinical Case:
a 51 year old man presented with clinical history of alcoholism and systemic arterial hypertension, and he developed limb ulcers, edema and uremic syndrome. Three week later, the patient died as a consequence of sepsis from Staphylococcus aureus. We emphasize the diagnostic approach of calciphylaxis, metabolic syndrome and comorbidities, cardiovascular and renal failure risk factors.
Conclusions:
the hyperuricemia is included in the metabolic syndrome, as the result of genetic and behavioral factors. It is recognized as a cardiovascular risk. For this reason we must consider it in the clinical practice guidelines for the prevention and treatment of diseases with high mortality.
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