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Updated: May 11, 2026
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Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
Published on: December 26, 2019
Risk factors for a poor hematopoietic stem cell mobilization
Ayhan Donmez1, Fergun Yilmaz, Nihal Gokmen
1Ege University Medical School Hospital, Department of Hematology, 35100 Izmir, Turkey.
Summary
Poor stem cell mobilization impacts autologous stem cell transplantation outcomes. Lymphoma diagnosis, advanced age, and higher weight are key risk factors for mobilization failure.
Area of Science:
- Hematology
- Transplantation Medicine
- Oncology
Background:
- Autologous stem cell transplantation (ASCT) relies on effective stem cell mobilization.
- Poor stem cell mobilization presents a significant clinical challenge, potentially impacting transplant success rates.
Purpose of the Study:
- To identify risk factors associated with poor stem cell mobilization in patients undergoing ASCT.
- To analyze the influence of patient demographics and diagnosis on mobilization efficiency.
Main Methods:
- Retrospective review of data from 165 patients who underwent stem cell mobilization.
- Statistical analysis, including odds ratios, to determine significant risk factors for poor mobilization.
Main Results:
- 16.4% of patients (27 out of 165) experienced poor stem cell mobilization.
- Mobilization failure rates varied by diagnosis: lymphoma (25.4%), acute leukemia (15.4%), amyloidosis (14.3%), and multiple myeloma (9.6%).
- Significant risk factors identified were lymphoma diagnosis (OR=6.02), advanced age (OR=1.05), and increased weight (OR=1.03).
Conclusions:
- Lymphoma diagnosis is the most critical risk factor for poor stem cell mobilization in ASCT.
- Clinicians should consider heightened mobilization risks in lymphoma patients and proactively plan for potential remobilization strategies.
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