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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

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Related Experiment Video

Updated: May 11, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

[Epigenetic regulation in neuronal differentiation and brain function].

Laetitia Kasprzyk1, Pierre-Antoine Defossez, Benoît Miotto

  • 1Unité d'Épigénétique et Destin Cellulaire, CNRS UMR7216, Université Paris Diderot 35, rue Hélène Brion, 75205 Paris Cedex 13, France.

Biologie Aujourd'Hui
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

DNA methylation impacts gene transcription and cellular processes. Environmental factors dynamically alter DNA methylation, influencing neuron function and potentially leading to behavioral disorders.

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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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Last Updated: May 11, 2026

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Area of Science:

  • Epigenetics and Molecular Biology
  • Neuroscience

Context:

  • DNA methylation is crucial for gene regulation and cellular functions like development and differentiation.
  • Environmental factors (drugs, pollutants, social environment) can modify DNA methylation patterns across organs.
  • A dynamic interplay exists between environment, DNA methylation, and neuron function.

Purpose:

  • To summarize the field of DNA methylation and its environmental influences.
  • To highlight the molecular functions of DNA methylation.
  • To discuss proteins that interact with methylated DNA.

Summary:

  • DNA methylation compacts chromatin and represses gene transcription, playing roles in development, X-chromosome inactivation, and differentiation.
  • Environmental cues dynamically alter DNA methylation patterns, affecting various organs, particularly the brain.
  • This environmental-epigenetic crosstalk is implicated in memory, addiction, and behavioral disorders.

Impact:

  • Provides a comprehensive overview of DNA methylation's role in biological processes and disease.
  • Highlights the molecular mechanisms underlying environmental influences on epigenetics.
  • Establishes DNA methylation as a key player in the etiology of neurological and behavioral conditions.