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Updated: May 11, 2026

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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Modified emulsion solvent evaporation method for fabricating core-shell microspheres.

Chao-Da Xiao1, Xiang-Chun Shen, Ling Tao

  • 1Department of Pharmaceutics, Guiyang Medical University, No. 9 Beijing Road, 550004 Guiyang, China.

International Journal of Pharmaceutics
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

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Researchers developed improved core-shell microspheres for drug delivery using a selective dissolution technique. This method enhances polymer phase separation, reducing initial drug release and enabling sustained delivery.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Core-shell microspheres are vital for controlled drug delivery.
  • Traditional solvent evaporation methods struggle with complete polymer phase separation.
  • Uncontrolled phase separation leads to inconsistent drug release profiles.

Purpose of the Study:

  • To enhance phase separation in core-shell microsphere fabrication.
  • To achieve controlled drug delivery with reduced initial burst release.
  • To optimize the preparation of poly(l-lactic-co-glycolic acid) (PLGA) and poly(l-lactic acid) (PLLA) core-shell microspheres.

Main Methods:

  • Utilized a selective dissolution technique with ethyl acetate (EtAc) to improve polymer phase separation.
  • Fabricated core-shell microspheres using PLGA and PLLA with aspirin as the model drug.

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Last Updated: May 11, 2026

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  • Investigated the effect of dichloromethane (DCM)/EtAc ratio on microsphere morphology and structure.

    • Main Results:

    • Optimized EtAc concentration (2 ml) resulted in a well-defined core-shell structure (PLLA core, PLGA shell).
    • Differential scanning calorimetry (DSC) confirmed complete polymer phase separation with two distinct melting points.
    • Achieved sustained aspirin release for over 456 hours with minimal initial burst release (3.49%).

    Conclusions:

    • The selective dissolution technique effectively improves phase separation in core-shell microsphere fabrication.
    • Optimized PLGA/PLLA core-shell microspheres offer a promising platform for controlled drug delivery.
    • This method significantly reduces initial burst release, enhancing therapeutic efficacy.