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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...

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Related Experiment Video

Updated: May 11, 2026

Assessing Specificity of Anticancer Drugs In Vitro
09:39

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

[Anticancer drug adherence].

Fabien Despas1, Henri Roche, Guy Laurent

  • 1CHU de Toulouse, centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, service de pharmacologie clinique, 37, allées Jules-Guesde, 31000 Toulouse, France. fabien.despas@univ-tlse3.fr

Bulletin Du Cancer
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

Patient adherence to cancer therapy is critical for optimal outcomes but is often poor, especially with oral medications. Addressing adherence requires understanding risk factors and employing multiple measurement methods.

Keywords:
adherencecancerdrugsocial pharmacology

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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Last Updated: May 11, 2026

Assessing Specificity of Anticancer Drugs In Vitro
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Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Area of Science:

  • Oncology
  • Pharmacology
  • Health Services Research

Context:

  • Recent decades have seen numerous anticancer drugs improve survival, transforming cancer into a chronic condition.
  • High drug costs, adverse effects, and dose-dependent efficacy underscore the importance of adherence in cancer therapy.
  • Patient adherence is understudied in many cancers, particularly hematologic malignancies, and is often poor for prolonged oral therapies.

Purpose:

  • To review the critical role of adherence in cancer therapy for optimizing the benefit-risk ratio.
  • To explore challenges in measuring adherence and identify risk factors for nonadherence.
  • To discuss strategies for preventing nonadherence and advocate for a social pharmacology approach in future research.

Summary:

  • Adherence to anticancer drugs is crucial but frequently suboptimal, especially for oral and long-term treatments.
  • Both patient and physician nonadherence occur, with patient adherence influenced by age, socioeconomic factors, and disease stage.
  • Multiple methods are needed to accurately measure adherence, and prospective studies should integrate social pharmacology principles.

Impact:

  • Highlights the critical need to address patient and physician nonadherence to maximize the effectiveness of novel cancer therapies.
  • Emphasizes the limitations of current adherence measurement tools and the necessity for complementary approaches.
  • Recommends a multidisciplinary research framework, incorporating medicine, psycho-sociology, and economics, to better understand and improve cancer treatment adherence.