Related Experiment Video
Updated: May 11, 2026

Imaging Vital and Non-vital Brain Pericytes in Brain Slices following Subarachnoid Hemorrhage
Published on: August 18, 2023
[Reangiography after perimesencephalic subarachnoid hemorrhage]
A Ringelstein1, O Mueller, O Timochenko
1Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147 Essen, Deutschland. adrian.ringelstein@uk-essen.de
Repeated digital subtraction angiography (DSA) rarely detects vascular lesions in perimesencephalic subarachnoid hemorrhage (SAH) cases with initially negative imaging. However, finding a source impacts treatment and prognosis, especially for posterior circulation aneurysms.
Area of Science:
- Neurology
- Radiology
- Vascular Imaging
Background:
- Perimesencephalic subarachnoid hemorrhage (SAH) diagnosis often involves initial negative noninvasive and invasive neurovascular imaging.
- Digital subtraction angiography (DSA), computed tomography angiography (CTA), and magnetic resonance angiography (MRA) are common diagnostic tools.
Purpose of the Study:
- To evaluate the diagnostic yield of repeated DSA in identifying causative vascular lesions.
- To assess the clinical significance of findings from repeated DSA in perimesencephalic SAH patients.
Main Methods:
- A retrospective analysis of 750 SAH patients over 10 years.
- Focused on 30 patients with perimesencephalic SAH and initially negative neurovascular imaging.
- Assessed the value of repeat DSA for lesion detection.
Main Results:
- Repeated DSA identified a causative vascular lesion in only 1 patient (3.3%).
- No lesions were detected in the remaining patients undergoing repeat DSA.
Conclusions:
- Repeated DSA is valuable in rare perimesencephalic SAH cases with initially negative imaging.
- Detecting a hemorrhage source, particularly posterior circulation aneurysms, has significant therapeutic and prognostic implications.
- Repeat DSA is recommended despite complication risks due to its potential impact on patient management.
Related Concept Videos
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology

