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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
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Extending...
Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...

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Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
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Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

Nociception and autonomic nervous system.

P Cortelli1, G Giannini, V Favoni

  • 1Dipartimento di Scienze Biomediche e NeuroMotorie-DIBINEM, Headache Unit, Ospedale Bellaria, IRCCS Istituto di Scienze Neurologiche, Alma Mater Studiorum-Università di Bologna, Via Altura, 3, 40139 Bologna, Italy. pietro.cortelli@unibo.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

Pain involves unpleasant sensory and emotional experiences, potentially linked to tissue damage. This review explores pain perception and its connections with the autonomic nervous system.

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Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
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Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
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Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
10:25

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Published on: January 26, 2012

Area of Science:

  • Neuroscience
  • Physiology
  • Pain Research

Background:

  • The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience linked to tissue damage.
  • Pain perception is intertwined with interoception, the sense of the body's physiological state, including temperature and other bodily feelings.
  • These feelings possess a significant affective aspect, influencing emotion, motivation, and behavior, highlighting their homeostatic role.

Purpose of the Study:

  • To review the neural structures involved in pain perception.
  • To examine the connections between the pain matrix and the autonomic nervous system.
  • To understand the interaction between pain sensation and autonomic control.

Main Methods:

  • Literature review of studies on pain perception.
  • Analysis of neural pathways connecting pain pathways and autonomic control centers.
  • Exploration of the affective and homeostatic roles of pain and related feelings.

Main Results:

  • Pain perception involves complex neural interactions beyond simple tissue damage.
  • The affective component of pain is crucial for its homeostatic function.
  • Significant overlap exists between neural structures processing pain and those regulating autonomic functions.

Conclusions:

  • Pain perception is intricately linked with the autonomic nervous system.
  • Understanding these connections is vital for comprehending the full scope of pain and its physiological impact.
  • This review highlights the importance of considering the autonomic nervous system in pain research and management.