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Related Experiment Video

Updated: May 11, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Psychiatric screening for migraine patients.

O Gambini1, B Biagianti, L Grazzi

  • 1Dipartimento di Scienze della Salute, Università degli Studi di Milano - AO San Paolo, Via A. di Rudinì 8/A, 20142 Milan, Italy. orsola.gambini@unimi.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 23, 2013
PubMed
Summary

Chronic migraine patients with medication overuse often have psychiatric issues. Detoxification helps, but a multidisciplinary approach is needed for lasting improvement in migraine and related disabilities.

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Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Migraine patients exhibit higher rates of psychiatric disorders compared to the general population.
  • Psychiatric comorbidities can complicate migraine presentation and contribute to medication overuse.
  • Chronic migraine with medication overuse presents significant challenges for headache clinics.

Purpose of the Study:

  • To investigate the impact of clinical severity, affective states, and medication attitudes on functioning in chronic migraineurs with medication overuse during detoxification.
  • To determine if these factors predict long-term outcomes one year after withdrawal.

Main Methods:

  • A cohort of 63 chronic migraineurs with medication overuse and severe disability were assessed at detoxification.
  • The same participants were re-evaluated one year after medication withdrawal.

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  • Key measures included clinical severity, affective states, attitudes toward medication, and overall functioning.

    • Main Results:

    • Detoxification led to partial improvements in clinical and affective measures.
    • Significant pain intensity and headache-related disability persisted post-detoxification.
    • Attitudes toward medication and dependence remained largely unchanged after withdrawal.

    Conclusions:

    • While detoxification offers partial benefits for chronic migraine with medication overuse, it does not fully resolve pain or disability.
    • The persistence of clinical severity and maladaptive cognitive profiles suggests a need for integrated treatment.
    • A multidisciplinary approach is recommended for chronic-relapsing migraineurs, addressing clinical, cognitive, and behavioral impairments.