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Updated: May 11, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
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Cluster headache: what has changed since 1999?

Massimo Leone1, Alberto Proietti Cecchini, Vincenzo Tullo

  • 1Department of Neurology, Headache Centre and Pain Neuromodulation Unit, C. Besta Neurological Institute and Foundation, Milan, Italy. leone.m@istituto-besta.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

Cluster headache (CH) and trigeminal autonomic cephalgias (TACs) involve specific brain areas, suggesting they are a unified headache spectrum syndrome. Recent studies provide evidence for this central origin of pain in these conditions.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Background:

  • The origin of pain in cluster headache (CH) and trigeminal autonomic cephalgias (TACs) has been debated.
  • Distinguishing between peripheral and central pain mechanisms is crucial for understanding these conditions.

Purpose of the Study:

  • To review recent evidence on the origin of pain in CH and TACs.
  • To consolidate findings from animal and human studies.

Main Methods:

  • Review of recent animal and human studies on CH and TACs.
  • Synthesis of existing data on pain mechanisms.

Main Results:

  • Growing evidence supports a central origin for pain in CH and TACs.
  • Specific brain areas are implicated in the pathophysiology of these headache disorders.

Conclusions:

  • CH and TACs can be considered a single spectrum-syndrome.
  • Involvement of specific brain regions underlies this unified headache presentation.