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Updated: May 11, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Update on future headache treatments.

Abraham J Nagy¹, Alan M Rapoport

¹Nevada Headache Institute, 8205 W Warm Springs Rd, Suite 210, Las Vegas, NV 89113, USA. anagy@kecenters.com

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|May 23, 2013

Summary

This summary is machine-generated.

New headache therapies are emerging, offering improved delivery of existing medications and targeting novel pathways like CGRP and SPG. Future treatments will explore targets such as TRPV1 and nitric oxide for better headache management.

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Area of Science:

Neurology
Pharmacology

Background:

Headache disorders represent common yet complex neurological conditions.
Current treatment options for acute and preventive therapies are limited, complicating management for specialists.

Purpose of the Study:

To review novel and emerging therapies for headache disorders.
To discuss advancements in drug delivery systems and new therapeutic targets.

Main Methods:

Review of novel drug delivery mechanisms for existing medications (e.g., sumatriptan, dihydroergotamine).
Discussion of therapies targeting newly discovered pathways (e.g., CGRP, SPG).
Exploration of emerging targets for future headache therapeutics (e.g., TRPV1, NO).

Main Results:

Several novel delivery systems are in development to overcome limitations of current methods.
New therapeutic targets, including CGRP receptor antagonists and SPG stimulation, show promise.
Future research is exploring a range of targets like TRPV1, NO, and orexin receptors.

Conclusions:

Advancements in understanding headache pathophysiology are driving the development of new treatments.
Emerging therapies, including novel delivery systems and new molecular targets, are expected to expand treatment options for headache specialists.