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Occipital neurostimulation in primary headaches: update
A Proietti Cecchini1, M Leone, V Tullo
1Department of Clinical Neuroscience, Headache Centre, Neurological Institute IRCCS C.Besta Foundation, Via Celoria, 11, 20133 Milan, Italy. proietti.a@istituto-besta.it
Summary
Peripheral occipital neurostimulation offers a promising alternative for patients with chronic migraine and cluster headache refractory to conventional treatments. This device-based therapy provides a less invasive option for managing severe, persistent headache disorders.
Area of Science:
- Neurology
- Neurosurgery
- Pain Medicine
Background:
- Chronic headache disorders, including migraine and cluster headache, often prove refractory to standard medical treatments.
- Patients may experience dissatisfaction or intolerance to medication side effects, necessitating alternative therapeutic strategies.
- Migraine is increasingly recognized as a chronic, potentially progressive condition warranting more aggressive management in refractory cases.
Purpose of the Study:
- To explore the potential of device-based therapies for drug-refractory chronic headache disorders.
- To evaluate the application and experience with peripheral occipital neurostimulation (ONS) in patients with chronic cluster headache and chronic migraine.
- To highlight ONS as a less invasive therapeutic opportunity for affecting brain function in difficult-to-treat headache populations.
Main Methods:
- Prospective evaluation of peripheral occipital neurostimulation (ONS).
- Focus on patients with drug-refractory chronic cluster headache and chronic migraine.
- Review of existing trials and case reports on ONS for various headache and craniofacial pain disorders.
Main Results:
- Peripheral occipital neurostimulation (ONS) has demonstrated benefits in diverse headache and craniofacial pain conditions.
- Chronic primary headache disorders have been the most extensively studied application for ONS.
- The study comments on the authors' specific experience applying ONS in challenging patient cohorts.
Conclusions:
- Device-based therapies like ONS represent a significant therapeutic opportunity for intractable headache disorders.
- Peripheral occipital neurostimulation is a viable, less invasive approach for managing drug-refractory chronic migraine and cluster headache.
- Further investigation and application of ONS are warranted for patients unresponsive to conventional treatments.

