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[Human leukocyte antigen (HLA) system in ophthalmology]

T Lapp1, D Reinhold, D Böhringer

  • 1Division of Infection and Immunity, University College London, UK. T.Lapp@ucl.ac.uk

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|May 23, 2013
PubMed

Various inflammatory and non-inflammatory eye diseases are associated with specific HLA isotypes. Therefore, HLA isotyping can be a useful diagnostic tool for these diseases and has already been shown to reduce the rejection rate of corneal allografts. Unfortunately, the volume of published data and the varying quality of these publications complicate obtaining good overview in this field. This review briefly summarizes the genetic structure of the HLA system and elucidates differences between HLA classes I and II in the context of antigen presentation. Possible mechanisms of HLA associations in the field of ophthalmology are discussed, and finally different tools (e.g. genome wide association studies) for assessing associations of HLA isotypes with different ocular diseases are examined.

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