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Updated: May 11, 2026

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
Current clinical immunotherapy targets in advanced nonsmall cell lung cancer (NSCLC)
Fiona McCarthy1, Rozita Roshani, Jeremy Steele
11.Barts Cancer Institute, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK. t.hagemann@qmul.ac.uk.
Abstract:
NSCLC remains one of the most challenging malignancies to treat. Despite the introduction of innovative therapies over the last decade, the 5-year survival of NSCLC is still <20%. Clearly, novel, therapeutic approaches are required. Targeting the immune system to derive meaningful clinical benefit has proved successful in various malignancies in recent years. As a result, there is renewed focus on the use of immunotherapy in lung cancer. In this review, we provide an overview of current immune-modulatory approaches in the treatment of NSCLC.
Insights
Non-small cell lung cancer (NSCLC) has a poor prognosis despite new treatments. This review explores immunotherapy, a promising approach for improving survival rates in NSCLC patients.
Area of Science:
- Oncology
- Immunology
- Medical Research
Background:
- Non-small cell lung cancer (NSCLC) presents significant treatment challenges.
- Current 5-year survival rates for NSCLC remain below 20%, necessitating novel therapeutic strategies.
- Recent successes in other cancers highlight the potential of immunotherapy.
Purpose of the Study:
- To review current immune-modulatory approaches for NSCLC treatment.
- To provide an overview of the evolving role of immunotherapy in lung cancer care.
Main Methods:
- Literature review of recent studies and clinical trials.
- Analysis of immune-modulatory strategies in NSCLC.
- Synthesis of current research on immunotherapy for lung cancer.
Main Results:
- Immunotherapy has shown promise in treating various malignancies.
- There is a growing focus on applying immunotherapy to lung cancer.
- Current immune-modulatory approaches are being investigated for NSCLC.
Conclusions:
- Novel therapeutic approaches are crucial for improving NSCLC outcomes.
- Immunotherapy represents a significant area of focus for future NSCLC treatment.
- Further research into immune-modulatory strategies may enhance patient survival in NSCLC.
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