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Published on: January 9, 2020
Adherence to raloxifene therapy: assessment methods and relationship with efficacy
J Finigan1, K Naylor, M A Paggiosi
1Academic Unit of Bone Metabolism, Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK, j.finigan@sheffield.ac.uk.
Summary
Electronic monitoring more accurately assesses patient adherence to raloxifene than tablet counting. Higher adherence to raloxifene treatment correlates with improved bone mineral density and reduced bone turnover markers.
Area of Science:
- Pharmacology
- Bone Metabolism
- Clinical Trials
Background:
- Accurate assessment of patient adherence to medication is crucial for treatment efficacy.
- Traditional methods like counting returned tablets may overestimate adherence.
- Electronic monitoring offers a more precise method for tracking medication adherence.
Purpose of the Study:
- To compare the accuracy of electronic monitoring versus tablet counting in assessing adherence to raloxifene.
- To investigate the association between medication adherence and bone response to raloxifene therapy.
Main Methods:
- Osteopenic women (50-80 years) received daily raloxifene for 2 years.
- Adherence was monitored using electronic bottle caps (MEMS) and tablet counts.
- Bone mineral density (BMD) and urinary N-terminal cross-linked telopeptide of type I collagen (NTX) were measured.
Main Results:
- Electronic monitoring (MEMS) revealed lower adherence than tablet counts, especially at lower adherence levels.
- MEMS adherence correlated with reduced bone turnover (NTX) and improved femoral neck BMD.
- Low adherence was associated with poorer BMD response across all measured sites.
Conclusions:
- Electronic monitoring provides a more accurate assessment of raloxifene adherence than tablet counting.
- Medication adherence significantly influences bone turnover and bone mineral density response to anti-resorptive therapy.
- Electronic monitoring is recommended for clinical trials to accurately assess adherence and its impact on treatment outcomes.
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