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Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Role of Hematopoietic Growth Factors

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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Receptor Downregulation in MVBs

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Differentiation of Common Myeloid Progenitor Cells

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Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

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Related Experiment Video

Updated: May 11, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Galectins in hematological malignancies.

Mirta Giordano¹, Diego O Croci, Gabriel A Rabinovich

¹Laboratorio de Inmunología Oncológica, Instituto de Investigaciones Médicas (IMEX/CONICET), Academia Nacional de Medicina, Buenos Aires, Argentina.

Current Opinion in Hematology

|May 23, 2013

Summary

Galectins play a key role in blood cancers by promoting tumor growth and immune evasion. Targeting galectins with inhibitors offers a promising new therapeutic strategy for hematological neoplasms.

Related Experiment Videos

Last Updated: May 11, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Area of Science:

Oncology
Immunology
Biochemistry

Background:

Galectins are lectin molecules with diverse intracellular and extracellular functions.
They are increasingly recognized for their roles in inflammation and cancer progression.

Purpose of the Study:

To review recent advances on the role of galectins in hematological neoplasms.
To highlight the therapeutic potential of targeting galectins in blood cancers.

Main Methods:

This is a review article, synthesizing existing research.
Focuses on functional studies and expression analysis of galectins in various hematological malignancies.

Main Results:

Galectin-1 and Galectin-3 are prominently implicated in oncohematology.
Increased Galectin-1 expression correlates with tumor progression in Hodgkin's lymphoma and chronic lymphocytic leukemia.
Galectin-3 supports chronic myelogenous leukemia and multiple myeloma.
Galectin-1 acts as a negative regulator of T-cell immunity in specific lymphomas.

Conclusions:

Galectins are crucial in hematological neoplasms, promoting tumor cell growth, survival, and immune escape.
Targeting galectins with specific inhibitors presents a viable therapeutic avenue to manage these diseases.