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Chemical stability of brompheniramine maleate in an oral liquid dosage form
Vishnu D Gupta1, Vikas S Gupta
1Pharmaceutics Division University of Houston Houston, Texas.
Abstract:
The chemical stability of brompheniramine maleate in an oral liquid dosage form was studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in the University of Houston (Houston, Texas) laboratory. The concentrations of the drug were directly related to peak heights, with an R value of 0.999. The percent relative standard deviation based on five injections was 1.0. The formulation was stable for at least 202 days when stored in amber-colored glass bottles at room temperature. The pH value of the formulation remained constant at 2.7 after 202 days of storage, and the physical appearance of the formulation did not change.
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