[Stability threshold of a tissue system]

Studies of changes in the cells adhesive force during spontaneous and induced cancerogenesis, as well as under the effect of cancerogenesis promotors permits to reveal the cells adhesion forces critical values which separate tissue states stable and unstable to blastomogenesis. These data are analysed proceeding from the concepts on generalized cooperative transitions in the membranes and their role in the control over biological systems. It is taken into account that the membranes and cytoskeleton elements are the most important systems of the tissue mechanical integration, and phase transitions proceeding in them must be reflected in the tissue mechanical properties.