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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

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Related Experiment Video

Updated: May 11, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

JAK-STAT signaling in stem cells.

Rachel R Stine1, Erika L Matunis

  • 1Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205 USA.

Advances in Experimental Medicine and Biology
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

The JAK-STAT signaling pathway is crucial for adult stem cell regulation across species. Misregulation of this pathway can lead to diseases, including cancers.

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Last Updated: May 11, 2026

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Area of Science:

  • Stem cell biology
  • Molecular signaling pathways
  • Developmental biology

Background:

  • Adult stem cells are vital for tissue regeneration and repair.
  • Stem cell regulation involves complex signaling networks to maintain homeostasis.
  • The Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a key regulator.

Purpose of the Study:

  • To review the role of JAK-STAT signaling in various adult stem cell niches.
  • To compare JAK-STAT pathway function in invertebrate and vertebrate stem cell systems.
  • To discuss the implications of JAK-STAT pathway dysregulation in disease.

Main Methods:

  • Comparative analysis of stem cell regulation across species.
  • Review of existing literature on JAK-STAT signaling in stem cell niches.
  • Examination of genetic and molecular studies in model organisms like Drosophila.

Main Results:

  • JAK-STAT signaling is conserved in regulating stem cell maintenance across diverse niches (germline, intestinal, hematopoietic, neuronal).
  • Studies in Drosophila have provided fundamental insights into JAK-STAT roles applicable to mammalian systems.
  • The pathway is essential for stem cell niche homeostasis.

Conclusions:

  • The JAK-STAT pathway is a critical regulator of adult stem cell function in multiple tissue types.
  • Understanding JAK-STAT signaling in model organisms advances knowledge of vertebrate stem cell biology.
  • Aberrant JAK-STAT signaling is implicated in various diseases, notably cancers.